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KMID : 0043319960190020112
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Archives of Pharmacal Research
1996 Volume.19 No. 2 p.112 ~ p.115
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Maltol, an Antioxidant Component of Korean Red Ginseng, Shows Little Prooxidant Activity
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Suh Dae-Yeon
Han Yong-Nam
Han Byung-Hoon
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Abstract
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Some antioxidant phenolic compounds exhibit prooxidant activity mainly due to their abilities to reduce Reducing ability and prooxidant activity of maltol, an antioxidant component of Korean red ginseng, were compared with those of pyrogallol. Maltol at 2 mM did not appreciably reduce and also failed to reduce nitroblue tetrazolium. Stimulation of hydroxyl radical mediated-deoxyribose degradation by pyrogallol was maximal at 60 .mu.M. Maltol stimulated the deoxyribose degradation to a much less extent, and a similar stimulatory effect was observed at a concentration of more than 100-fold higher than that of pyrogallol. The stimulatory effect of maltol reached a plateau over 1 mM, suggesting the removal of hydroxyl radicals by excess maltol. In bleomycin--DNA assay, maltol at 2 mM produced a 2.5-fold increase of the iron-bleomycin-dependent DNA degradation over the basal value, whereas pyrogallol at 10 .mu.M accelerated DNA degradation by ca. 10-fold. Furthermore, maltol inhibited -stimulated DNA degradation by bleomycin. These results strongly suggested that maltol is an antioxidant with little prooxidant activity.
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KEYWORD
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Maltol, Antioxidant Prooxidant acitivity, Deoxyribose method, Blemocycin assay
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